Description

ASSIST TM is our custom formulated B6 with magnesium supplement…. It is important to take the active co-enzyme form of B6, pyridoxal-5-phosphate (P-5-P.) along with magnesium. B6 in the form of P5P 30mg + magnesium blend of 100mg for anxiety, blood sugar control, insulin resistance, etc. 100 capsules per bottle

This product literally ASSISTS your body!

The usual dosage is 1 – 3 capsules spread throughout the day & taken with a meal (30mg of B6 from 50mg pyridoxal 5′-phosphate) + 100mg of magnesium glycinate chelate per capsule

FORMS OF B6: Pyridoxal 5-phosphate, or P-5-P, is the active form of Vitamin B6. The difference between regular Pyridoxine and P-5-P is that P-5-P does not need to undergo any more transformations as it is the target form of Vitamin B6. Pyridoxal 5-Phosphate plays the role of coenzyme or prosthetic group. P5P-based supplements are preferred over pyridoxine supplements because of minimal neurotoxicity observed in neuronal cell viability tests.

Vitamin B6 is involved in the following metabolic processes:

*Amino acid, glucose and lipid metabolism

*Neurotransmitter synthesis

*Histamine synthesis

*Hemoglobin synthesis and function

*Gene expression

Symptoms of Vitamin B6 deficiency:
Lack of energy and chronic fatigue: Vitamin B6 helps supply your body with energy by improving your metabolism. It has a vital role to play in protein metabolism – it helps your body break down the protein that you eat and produce energy quickly. So one very important pointer that you have a vitamin B6 deficiency is when you get fatigued quickly during exercise.
Brain function decline: Vitamin B6 vitamin helps your brain communicate with other parts of the body more efficiently. So, if you have a decline in muscle efficiency it could be a sign of vitamin B6 deficiency.
High Levels of amino acid Homocysteine: High levels of amino acid Homocysteine do not cause any symptoms that you can detect by yourself but tests can tell you if you have high levels of this amino acid in your body. And these high levels are directly linked to vitamin B6 deficiency. What high levels of homocysteine can do is cause heart attacks. But vitamin B6 helps keep a check on these levels to reduce your risk for a cardiovascular event.

Other symptoms of vitamin B6 deficiency are:

Changes in mood, such as depression, irritability, and anxiety
Confusion
Muscle pains
Fatigue
A worsening of PMS symptoms
And worsening of symptoms of anemia
As vitamin B6 is so important for nerve function, a deficiency is linked with neuro-psychiatric disorders like seizures, migraines, and chronic pain.
An increased risk of heart disease and rheumatoid arthritis
Higher risk for Alzheimer’s disease and other forms of dementia.
Dermatitis
Sleep difficulties
Neurological synnpotms
Trouble focusing
ADHD
Parkinsons
Hangover
Morning sickness

Vitamin B-6 functions in the brain to help form myelin and synthesizes the neurotransmitters serotonin and norepinephrine. Vitamin B-6 is found in vegetables, legumes, meat, dairy, eggs, fish and cereal grains. Because of its importance in proper brain function, pyridoxine deficiency or insufficiency has been implicated in many disorders involving the brain, including ADHD.

Vitamin B6 calms the nervous system and helps the body to produce neurotransmitters and so balance the neurotransmitter systems transmitting messages through it. No wonder then that numerous studies have connected this vitamin with ADD (Attention Deficit Disorder) and ADHD (Attention Deficit Hyperactivity Disorder).

Vitamin B6 intake is frequently low & this nutrient is commonly deficient in pregnant women, children, the elderly & the ill. It is also depleted by birth control pills, alcohol, tobacco, some antibiotics, blood pressure medication, and numerous other prescription drugs

Without adequate vitamin B6, the amino acids in dietary protein are not of much use to you. Vitamin B6 literally controls the amino acid absorption, metabolism & transformations in your body. It also directly participates in carbohydrate & fat metabolism, as well as the formation of red blood cells & antibodies. It is necessary for the absorption & utilization of certain minerals & is required for the proper functioning of over sixty enzyme systems in our bodies.

Many B6 supplements are the inactive pyridoxine HCL form. In some cases, supplementation of the pyridoxine HCL form singularly and in doses as low as 200 mg daily over 3 years caused a reversible numbness & tingling of the extremities. This problem was thought to be secondary to the liver’s inability to convert the pyridoxine HCL to the pyridoxal-5-phosphate form (which requires vitamin B2, magnesium & a well functioning liver.) Using P-5-P avoids this problem.*

Supplementation increases the production of serotonin, norepinephrine, GABA, dopamine, & other neurotransmitters.

*Is essential to any natural anti-depressant program

Helps to relieve premenstrual symptoms.*

Helps boost immunity.*
May be protective against some forms of cancer.*

May be effective with some forms of fertility.* Has anti-convulsant effects.*

Helps with skin disorders.*
Helps maintain healthy blood sugar levels. MUST be taken if you are experiencing any insulin resistance or diabetic tendencies.

Because this nutrient is so intricate to so many areas of brain/body functioning, it is important to list the myriad SYMPTOMS OF DEFICIENCY:

Depression* Nervousness* Irritability*
Slow learning* Poor dream recall* Dizziness* Fatigue* Cracks around mouth & eyes* Dermatitis & acne*
Inflamed eyes* Facial oiliness*

Stillbirths from deficiency during pregnancy* Decreased lymphocytes*
Decreased vitamin C levels*
PMS*

Increased sensitivity to sound* Water retention*
Decreased resistance to infection* Impaired wound healing*

Poor appetite*
AM nausea/vomiting*
Dental cavities*
Hair loss*
Fatigue*
Impaired calcium utilization* Decreased absorption of copper* Decreased iron status*
Decreased Vitamin B 12 absorption* Arthritis*
Muscular weakness*
Neuritis*
Carpal tunnel syndrome* Temporary limb paralysis* Numbness & tingling in the limbs* Anemia*
Elevated homocysteine levels* Seizures*
Low blood sugar*
Low glucose tolerance*
Abdominal pain*

Low iron/ferritin*

VITAMIN B6 AND PREGNANCY

NOTE FOR PREGNANCY: Folic acid: Low folate is associated with a 47% increased risk of miscarriage; having both low folate and low vitamin B6 increase miscarriage risk by 310%.Vitamin B6 is crucial for the healthy function of the brain and nervous system and thus plays a critical role in the development of your baby. Specifically, it’s necessary for the healthy production of serotonin and norepinephrine, key neurotransmitters.

Your baby requires a supply of Vitamin B6 for the healthy development of its brain and nervous system
B6 can resolve some cases of morning sickness
It helps you maintain healthy blood glucose levels
It plays a role in preventing several issues in newborns, including eczema and low birth weight

Many women are first recommended B6 supplementation early in pregnancy, when nausea and vomiting are at their worst, as B6 can significantly alleviate the issue.

Vitamin B6 and Miscarriage

High vitamin B6 lowers chance of miscarriage by 50% improves fertility by 120%

Homocysteine, folate, and vitamins B6 and B12 were measured in preconception plasma. Relative to women in the lowest quartile of vitamin B6, those in the third and fourth quartiles had higher odds of conception (odds ratio = 2.2; odds ratio = 1.6, respectively), and the adjusted odds ratio for early miscarriage in conceptive cycles was lower in the fourth quartile (odds ratio=0.5). Women with sufficient vitamin B6 had higher odds of conception (odds ratio = 1.4) and a lower adjusted odds ratio of early miscarriage in conceptive cycles (odds ratio=0.7) than did women with vitamin B6 deficiency. Poor vitamin B6 status appears to decrease the probability of conception and to contribute to the risk of early miscarriage in this population.

http://www.ncbi.nlm.nih.gov/pubmed/17478435

Vitamin B6, B2, B12 and folate lower in women who miscarry

The median levels of all B vitamins examined, i.e. folate, vitamins B2, B6, and B12, were lower in miscarriage cases compared to the controls, although the difference did not reach significance except for vitamin B6 intake, which resulted in the border of significance (2.1 vs. 1.8 mg). It is important to point out that multivitamin supplementation is low in the Mexican population, as was the case in this small study population. Thus, these findings need to be replicated in larger studies to fully evaluate the protective role of these vitamins on miscarriage risk.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890227/

Vitamin B6 can prevent stress from affecting fetal growth

High-dose vitamin B6 may counteract the adverse impact of glucocorticoids (which are increased by stress) on fetal growth.

http://linkinghub.elsevier.com/retrieve/pii/S0306987799909568

Vitamin B6 and Hormones

Vitamin B6 lowers prolactin

Vitamin B6 appears to reduce the production of prolactin, a hormone that causes testosterone to be taken up by tissues.

http://www.bentham.org/cnf/sample/cnf4-4/D0004NF.pdf

Vitamin B6 acts similarly to progesterone

Vitamin B₆ possesses progesterone-like effect but it does not intensify the action of progesterone. On the other hand, vitamin B₁₂ and vitamin A exhibit no progesterone-like effect and do not affect the action progesterone when they were given together.

http://www.springerlink.com/index/n3xp3xt315458323.pdf

Vitamin B6 increases progesterone

Administration of vitamin B6 at doses of 200-800 mg/day reduces blood estrogen, increases progesterone and results in improved symptoms under double-blind conditions.

http://www.ncbi.nlm.nih.gov/pubmed/6684167

B6 and ADHD/ADD

Deficiencies in B vitamins — particularly B6 — can cause irritability and fatigue. Adequate B6 levels can increase alertness and decrease anxiety-like symptoms. Foods high in B6 include wild-caught tuna, bananas, spinach, and salmon. https://pubmed.ncbi.nlm.nih.gov/16846100/

Zinc: Zinc is thought to help regulate the neurotransmitter dopamine — which occurs in insufficient levels in ADHD brains — and it may make methylphenidate more effective by improving the brain’s response to dopamine.² Zinc levels have been found to be low in some children with ADHD, and studies have found that taking zinc supplements reduces hyperactivity and impulsivity. Foods high in zinc include beef, spinach, pumpkin seeds, and shrimp.

In almost all cases of ADHD, Mg-B6 regimen for at least two months significantly modified the clinical symptoms of the disease: namely, hyperactivity and hyperemotivity/aggressiveness were reduced, school attention was improved. In parallel, the Mg-B6 regimen led to a significant increase in Erc-Mg values. When the Mg-B6 treatment was stopped, clinical symptoms of the disease reappeared in few weeks together with a decrease in Erc-Mg values. (Mousain-Bosc M, Roche M, Polge A, Pradal-Prat D, Rapin J, Bali JP. Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. I. Attention deficit hyperactivity disorders. Magnes Res. 2006 Mar;19(1):46-52. PMID: 16846100.)
B6 works as well as Ritalin – Back in 1979, a group of researcherscompared B6 to Ritalin (methylphenidate)-and found them equally effective in easing the symptoms of ADHD. They noted that B6 increased serotonin levels, but Ritalin didn’t.
Improving attention – In another study, researchers gave a pyridoxine-derived drug (Metadoxine) or a placebo to 36 adults with ADHD. The vitamin-based drug “significantly improved sustained and selective attention.”

We only endorse using the correct form of B6 called P-5-P. Please do not run to drug store and purchase lower quality, wrong form of B6 which can be toxic!

Assist B6 P5P